Great Ormond Street Hospital Children's Charity is committed to supporting high quality research with the potential to improve the health and wellbeing of children at Great Ormond Street Hospital (GOSH), through better diagnosis, treatment, improved care and cures. Our niche is the rapid translation of research for patient benefit.
Joint call for project grants from across the UK from Action Medical Research and Great Ormond Street Hospital Children’s Charity 2015-2016
DEADLINE FOR APPLICATION: TUESDAY 18 NOVEMBER 2014
Scope of call
Action Medical Research is teaming up with Great Ormond Street Hospital Children’s Charity to fund project grants from across the UK that have potential to save or improve the lives of children through prevention, better diagnosis and the development of new treatments for disease and disability. The emphasis will be on research likely to have clinical impact in the short to medium term (up to five-ten years).
Applications for co-funded projects will need to meet the remit and guidelines on the Action Medical Research website and demonstrate they have a potential to impact children who are treated or might be treated at Great Ormond Street Hospital and elsewhere.
Applications that are not eligible for co-funding but meet the remit of Action Medical Research alone will also be considered in this round.
Applications will be received and managed by Action Medical Research
Applicants should be employed in a UK based University, hospital or recognised research institute.
Applicants should check the Action Medical Research guidelines and exclusions for project grants.
Jointly-funded research awards will be subject to the standard Action Medical Research terms and conditions
The Principal Investigator(s) will be informed in the award letter if an award is being jointly funded by Action Medical Research and Great Ormond Street Hospital Children’s Charity and the researchers will need to acknowledge the funding of both charities.
Up to £2,000,000 is available to spend on co-funded projects in this round with outcomes to be announced in July 2015. Projects of up to three years duration will be considered, to a maximum cost of around £200,000.
How to apply
All applicants will need to complete a two page outline application form which can be downloaded from the Action Medical Research website. If you require further information please contact Action Medical Research at: firstname.lastname@example.org
You can also contact the Research Department and Dr Tracy Swinfield, Director of Research on 01403 327407.
Clinical Research Starter Grants 2015-2016
CALL WILL OPEN IN NOVEMBER 2014
Scope of call
Great Ormond Street Hospital Children's Charity is inviting clinically focused pilot or feasibility studies with strong potential to benefit patients and have an impact at the point-of-care. Studies should allow investigators to gather preliminary data or samples and/or develop a research question. This is intended to be pump-prime funding that will help investigators gather proof-of-concept data needed to move the research into the next stage. It is expected that applicants will leverage the Great Ormond Street Hospital Children's Charity grant to obtain funding from the NIHR or another external funding body. Lead Applicants must be research-active GOSH health professionals and have a contract or honorary contract with GOSH.
We particularly encourage proposals that:
Are highly translational and likely to benefit patients directly.
Address problems that will have an impact at the point-of-care.
Make the most of the unique patient population at GOSH.
Demonstrate real partnership between clinical and academic researchers. Rapid progress will often need a multidisciplinary approach, or sharing of resources and knowledge.
Up to £500,000 is available to spend under this call and it is anticipated that we will fund a range of proposals from different investigators. Funding will be provided for the direct costs of research (such as research staff and consumables) and will not cover consultant PAs or team-leader salary time. Typically, projects will be between 12–18 months duration.
Previous National Funding Calls
Translational Paediatric Rare Disease Research 2014-2015
We received a total of 43 outline applications in response to the charity’s joint national call for outline proposals in November 2013.
Following a triage meeting held on 19 December 2013, 11 full applications were invited to be submitted in February 2014 for full external peer review.
A National Assessment Panel met on 12 May 2014 to review these applications. Present at the meeting were Professor Timothy Barrett, Dr Colin Michie, Dr William Van't Hoff, Professor Phillip Beales, Professor David Jones, Professor Jill Clayton-Smith, Professor Andy Copp and Dr Sahar Mansour.
The following seven projects totalling £1,000,000 were awarded grants:
Table showing the seven projects awarded grants for the Translational Paediatric Rare Disease Research funding call in 2014-2015
|Lead investigator ||Host institution ||Total ||Project title |
|John Anderson ||UCL Institute of Child Health ||£33,000 ||Exploring gene therapy approaches for neuroblastoma using a patient's own gamma delta T cells: Application for running costs |
|Philippa Mills ||UCL Institute of Child Health ||£110,197 ||Rapid identification of children whose epilepsy can be treated with vitamin B6 |
|Philip Stanier ||UCL Institute of Child Health ||£134,026 ||Clinical and molecular characterisation of a new intellectual disability-cerebellar ataxia syndrome |
|Brian Bigger ||University of Manchester ||£358,626 ||Development of myeloid driven autologous haematopoietic stem cell gene therapy for Sanfilippo disease |
|Phillip Beales ||UCL Institute of Child Health ||£30,506 ||Evaluating alternative genetic therapies for Bardet-Biedl Syndrome |
|Hannah Mitchison ||UCL Institute of Child Health ||£133,489 ||Next generation sequencing to stratify and personalise the genetic basis of motile cilia disease |
|Fenella Kirkham ||UCL Institute of Child Health ||£200,156 ||Potential Reversibility of structural brain abnormalities by preventing hypoxia in sickle cell anaemia |
Translational Paediatric Biomarker Research funding call (2013-2014)
We received a total of 38 outline applications in response to the charity’s joint national call for outline proposals in November 2012.
Following a triage meeting held on 10 January 2013, 16 full applications were invited to be submitted in March 2013 for full external peer review.
A National Assessment Panel met on 28 June 2013 to review these applications. Present at the meeting were Professor David Armstrong (Panel Chair), Dr Colin Michie, Professor Tim Barrett, Dr Peter Grabowski and Dr William van’t Hoff, with scores received in advance from Professor Bobby Gaspar.
The following six projects totalling £947,574 were awarded grants:
Table showing the six projects awarded grants for the Translational Paediatric Biomarker funding call in 2012-2013
|Lead investigator ||Host institution ||Total || Project title |
|Paul Humphries ||University College London ||£100,500 ||Whole body PET-MRI in paediatric and adolescent lymphoma |
|Michael Levin ||Imperial College London ||£260,246 ||A rapid diagnostic test to discriminate bacterial and viral infection in febrile children based on RNA expression signature |
|David Michod ||UCL Institute of Child Health ||£40,500 ||Phosphorylation of the H3.3 chaperone DAXX as a new biomarker and a new target for treatment of high grade gliomas in children |
|David Long ||UCL Institute of Child Health ||£195,526 ||Angiopoietin-2 as a biomarker and mediator of cardiovascular disease in children |
|Vivek Muthurangu ||Instiute of Cardiovascular Science ||£184,975 ||Magnetic resonance augmented exercise testing: a novel biomarker in paediatric pulmonary hypertension |
|Kathy Pritchard-Jones ||UCL Institute of Child Health ||£165,827 ||Prognostic value of 1q gain in Wilms' tumour |