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Research calls

Great Ormond Street Hospital Children's Charity is committed to supporting high quality research with the potential to improve the health and wellbeing of children at Great Ormond Street Hospital (GOSH), through better diagnosis, treatment, improved care and cures. Our niche is the rapid translation of research for patient benefit. 

Researcher in laboratory

Clinical Research Starter Grants 2014-2015

THIS CALL IS NOW CLOSED.

Scope of call

Great Ormond Street Hospital Children's Charity is inviting clinically focused pilot or feasibility studies with strong potential to benefit patients and have an impact at the point-of-care. Studies should allow investigators to gather preliminary data or samples and/or develop a research question. This is intended to be pump-prime funding that will help investigators gather proof-of-concept data needed to move the research into the next stage. It is expected that applicants will leverage the Great Ormond Street Hospital Children's Charity grant to obtain funding from the NIHR or another external funding body. Lead Applicants must be research-active GOSH health professionals and have a contract or honorary contract with GOSH.

We particularly encourage proposals that:

  • Are highly translational and likely to benefit patients directly.

  • Address problems that will have an impact at the point-of-care.

  • Make the most of the unique patient population at GOSH.

  • Demonstrate real partnership between clinical and academic researchers. Rapid progress will often need a multidisciplinary approach, or sharing of resources and knowledge. 

Funding available

Up to £500,000 is available to spend under this call and it is anticipated that we will fund a range of proposals from different investigators. Funding will be provided for the direct costs of research (such as research staff and consumables) and will not cover consultant PAs or team-leader salary time. Typically, projects will be between 12–18 months duration.

National call for applications in Translational Paediatric Rare Disease Research 2014-2015

THIS CALL IS NOW CLOSED.

Scope of call

Rare diseases are currently under-researched and under-resourced and they can often leave patients and their families feeling isolated and vulnerable. Rare diseases have a low prevalence but a high level of complexity. For rare syndromes, diagnosis may be difficult and delayed due to limited scientific knowledge and clinical recognition of the disease. 75 per cent of rare diseases affect children. GOSH specialises in the care of children with rare syndrome and hosts 19 nationally commissioned services for such conditions, the largest number in a single NHS Trust. The charity is committed to investment in rare disease research and in addition to this call is developing a new Centre for Research into Rare Disease in Children, a £90 million research facility, due to be completed in 2017.

Research that will improve the diagnosis of rare diseases will be prioritised and for the purposes of this call the definition of a rare disease is one that affects fewer than five in 10,000 people.

We particularly encourage highly translational proposals that:

  • Address problems that will have an impact at the point-of-care

  • Are based on practical research that will have an impact on health services and delivery

  • Have a robust study design and established access to the relevant patient population

  • Are multidisciplinary in nature and demonstrate real partnership between clinical and academic researchers

  • Have the potential to leverage Great Ormond Street Hospital Children's Charity funding and lead to a larger grant

Funding available

Up to £1 million is available to spend under this call and it is anticipated that we will fund a range of proposals from different investigators and institutions. Funding will be provided for the direct costs of research (such as research staff and consumables) and will not cover consultant PAs or team-leader salary time. Typically, projects will be up to three years duration.

Who may apply?

Great Ormond Street Hospital Children's Charity is inviting project grant applications from across the UK that have the potential to impact patients at GOSH and elsewhere.

  

Previous National Funding Calls

Translational Paediatric Biomarker Research funding call (2013-2014)

We received a total of 38 outline applications in response to the charity’s joint national call for outline proposals in November 2012.

Following a triage meeting held on 10 January 2013, 16 full applications were invited to be submitted in March 2013 for full external peer review.

A National Assessment Panel met on 28 June 2013 to review these applications. Present at the meeting were Professor David Armstrong (Panel Chair), Dr Colin Michie, Professor Tim Barrett, Dr Peter Grabowski and Dr William van’t Hoff, with scores received in advance from Professor Bobby Gaspar.

The following six projects totalling £947,574 were awarded grants:

Table showing the six projects awarded grants for the Translational Paediatric Biomarker funding call in 2012-2013
Lead investigator Host institution Total Project title
Paul Humphries University College London £100,500 Whole body PET-MRI in paediatric and adolescent lymphoma
Michael Levin Imperial College London £260,246  A rapid diagnostic test to discriminate bacterial and viral infection in febrile children based on RNA expression signature
David Michod UCL Institute of Child Health £40,500 Phosphorylation of the H3.3 chaperone DAXX as a new biomarker and a new target for treatment of high grade gliomas in children
David Long UCL Institute of Child Health £195,526 Angiopoietin-2 as a biomarker and mediator of cardiovascular disease in children
Vivek Muthurangu Institute of Cardiovascular Science £184,975 Magnetic resonance augmented exercise testing: a novel biomarker in paediatric pulmonary hypertension
Kathy Pritchard-Jones UCL Institute of Child Health £165,827 Prognostic value of 1q gain in Wilms' tumour

 

Children with cancer UK logo

CHILDREN with CANCER UK and GOSH Children's Charity joint national funding call for applications in translational paediatric cancer research (2012-2013)

We received a total of 33 outline applications in response to the charity’s joint national call for outline proposals in November 2011.

Following a triage meeting held on 5 December 2011, 15 full applications were invited to be submitted in February 2012 for full external peer review.

A joint research assessment panel met on 15 May 2012 to review these applications. Present at the meeting were Professor David Armstrong (Panel Chair), Dr Nicholas Goulden, Professor Geoff Pilkington, Professor Kathy Pritchard-Jones, Professor Keith Wheatley and Dr William van’t Hoff, with scores received in advance from Professor Faith Gibson and Professor Malcolm Taylor.

The following eight projects totalling £1,572,231 were awarded grants:

Table showing the eight projects awarded grants for the CHILDREN with CANCER UK and GOSH Children's Charity research call 2011-12
Lead investigator Host institution Total Project title
John Anderson UCL Institute of Child Health £302,390 Combinatorial targeting of anaplastic lymphoma kinase for neuroblastoma immunotherapy
Nicholas Coleman University of Cambridge £99,840 Novel genetic markers for blood-based monitoring of treatment response in common childhood cancers
Tariq Enver UCL Cancer Institute £284,915 Feasibility and clinical and scientific value of leukaemic stem cell monitoring during acute lymphoblastic leukaemia therapy
Rob Mairs University of Glasgow £158,857

Assessment of [131I]MIBG in combination with cytotoxic drugs for neuroblastoma therapy

Juan Pedro Martinez-Barbera UCL Institute of Child Health £79,152 Development of novel chemical therapies against the paediatric form of human craniopharyngioma
Vaskar Saha University of Manchester £281,222 Optimisation of the use of L-asparaginase and dexamethasone in childhood acute lymphoblastic leukaemia
 Janet Shipley Institute of Cancer Research  £227,368 Preclinical testing of FGFR inhibitors for the treatment of rhabdomyosarcoma
 Andrew Stocker UCL Institute of Child Health  £138,488 Combination treatments to drive neuroblastoma tumour differentiation and senescence