[Skip to content]

.

Research calls

Great Ormond Street Hospital Children's Charity is committed to supporting high quality research with the potential to improve the health and wellbeing of children at Great Ormond Street Hospital (GOSH), through better diagnosis, treatment, improved care and cures. Our niche is the rapid translation of research for patient benefit. 

AMR logo

Joint call for project grants from across the UK from Action Medical Research and Great Ormond Street Hospital Children’s Charity 2015-2016 

CALL OPEN

DEADLINE FOR APPLICATION: TUESDAY 18 NOVEMBER 2014 

Scope of call

Action Medical Research is teaming up with Great Ormond Street Hospital Children’s Charity to fund project grants from across the UK that have potential to save or improve the lives of children through prevention, better diagnosis and the development of new treatments for disease and disability. The emphasis will be on research likely to have clinical impact in the short to medium term (up to five-ten years).

Applications for co-funded projects will need to meet the remit and guidelines on the Action Medical Research website and demonstrate they have a potential to impact children who are treated or might be treated at Great Ormond Street Hospital and elsewhere.

Applications that are not eligible for co-funding but meet the remit of Action Medical Research alone will also be considered in this round.

  • Applications will be received and managed by Action Medical Research

  • Applicants should be employed in a UK based University, hospital or recognised research institute.

  • Applicants should check the Action Medical Research guidelines and exclusions for project grants.
    Jointly-funded research awards will be subject to the standard Action Medical Research terms and conditions

  • The Principal Investigator(s) will be informed in the award letter if an award is being jointly funded by Action Medical Research and Great Ormond Street Hospital Children’s Charity and the researchers will need to acknowledge the funding of both charities.

Funding available

Up to £2,000,000 is available to spend on co-funded projects in this round with outcomes to be announced in July 2015. Projects of up to three years duration will be considered, to a maximum cost of around £200,000.

How to apply

All applicants will need to complete a two page outline application form which can be downloaded from the Action Medical Research website. If you require further information please contact Action Medical Research at:  applications@action.org.uk

You can also contact the Research Department and Dr Tracy Swinfield, Director of Research on 01403 327407. 

 

Clinical Research Starter Grants 2015-2016

 CALL WILL OPEN IN NOVEMBER 2014

Scope of call

Great Ormond Street Hospital Children's Charity is inviting clinically focused pilot or feasibility studies with strong potential to benefit patients and have an impact at the point-of-care. Studies should allow investigators to gather preliminary data or samples and/or develop a research question. This is intended to be pump-prime funding that will help investigators gather proof-of-concept data needed to move the research into the next stage. It is expected that applicants will leverage the Great Ormond Street Hospital Children's Charity grant to obtain funding from the NIHR or another external funding body. Lead Applicants must be research-active GOSH health professionals and have a contract or honorary contract with GOSH.

We particularly encourage proposals that:

  • Are highly translational and likely to benefit patients directly.

  • Address problems that will have an impact at the point-of-care.

  • Make the most of the unique patient population at GOSH.

  • Demonstrate real partnership between clinical and academic researchers. Rapid progress will often need a multidisciplinary approach, or sharing of resources and knowledge.

Funding available

Up to £500,000 is available to spend under this call and it is anticipated that we will fund a range of proposals from different investigators. Funding will be provided for the direct costs of research (such as research staff and consumables) and will not cover consultant PAs or team-leader salary time. Typically, projects will be between 12–18 months duration.

  

Previous National Funding Calls

Translational Paediatric Rare Disease Research 2014-2015

We received a total of 43 outline applications in response to the charity’s joint national call for outline proposals in November 2013.

Following a triage meeting held on 19 December 2013, 11 full applications were invited to be submitted in February 2014 for full external peer review.

A National Assessment Panel met on 12 May 2014 to review these applications. Present at the meeting were Professor Timothy Barrett, Dr Colin Michie, Dr William Van't Hoff, Professor Phillip Beales, Professor David Jones, Professor Jill Clayton-Smith, Professor Andy Copp and Dr Sahar Mansour.

The following seven projects totalling £1,000,000 were awarded grants:

Table showing the seven projects awarded grants for the Translational Paediatric Rare Disease Research funding call in 2014-2015
Lead investigator Host institution Total Project title
John Anderson UCL Institute of Child Health £33,000  Exploring gene therapy approaches for neuroblastoma using a patient's own gamma delta T cells: Application for running costs
Philippa Mills UCL Institute of Child Health £110,197 Rapid identification of children whose epilepsy can be treated with vitamin B6
Philip Stanier UCL Institute of Child Health  £134,026 Clinical and molecular characterisation of a new intellectual disability-cerebellar ataxia syndrome
Brian Bigger University of Manchester  £358,626 Development of myeloid driven autologous haematopoietic stem cell gene therapy for Sanfilippo disease
Phillip Beales UCL Institute of Child Health £30,506 Evaluating  alternative genetic therapies for Bardet-Biedl Syndrome
Hannah Mitchison UCL Institute of Child Health  £133,489 Next generation sequencing to stratify and personalise the genetic basis of motile cilia disease
Fenella Kirkham UCL Institute of Child Health £200,156 Potential Reversibility of structural brain abnormalities by preventing hypoxia in sickle cell anaemia

 

Laboratory worker

Translational Paediatric Biomarker Research funding call (2013-2014)

We received a total of 38 outline applications in response to the charity’s joint national call for outline proposals in November 2012.

Following a triage meeting held on 10 January 2013, 16 full applications were invited to be submitted in March 2013 for full external peer review.

A National Assessment Panel met on 28 June 2013 to review these applications. Present at the meeting were Professor David Armstrong (Panel Chair), Dr Colin Michie, Professor Tim Barrett, Dr Peter Grabowski and Dr William van’t Hoff, with scores received in advance from Professor Bobby Gaspar.

The following six projects totalling £947,574 were awarded grants:

Table showing the six projects awarded grants for the Translational Paediatric Biomarker funding call in 2012-2013
Lead investigator Host institution Total Project title
Paul Humphries University College London £100,500 Whole body PET-MRI in paediatric and adolescent lymphoma
Michael Levin Imperial College London  £260,246 A rapid diagnostic test to discriminate bacterial and viral infection in febrile children based on RNA expression signature
David Michod UCL Institute of Child Health £40,500 Phosphorylation of the H3.3 chaperone DAXX as a new biomarker and a new target for treatment of high grade gliomas in children
David Long UCL Institute of Child Health  £195,526  Angiopoietin-2 as a biomarker and mediator of cardiovascular disease in children            
Vivek Muthurangu Instiute of Cardiovascular Science £184,975  Magnetic resonance augmented exercise testing: a novel biomarker in paediatric pulmonary hypertension
Kathy Pritchard-Jones UCL Institute of Child Health £165,827 Prognostic value of 1q gain in Wilms' tumour