Clinical Research Starter Grants

The Clinical Research Starter Grant is for a clinically-focused pilot of feasibility studies that will allow investigators to gather preliminary data or samples and/or develop a research question.

2016–2017 funding call

We received a total of 32 outline applications in response to the charity's call for applications.

Following a triage meeting held on 25 January 2016, 16 full applications were invited to be submitted for full external peer review.

The charity's Research Assessment Panel met on 12 May 2016 to review these applications.

The following six projects totalling £567,154 were awarded grants.

Lead investigator Host institution Total Project title
Professor Paul Gissen UCL Great Ormond Street Institute of Child Health £81,649 Establishing a platform for high-content drug screening in neurological diseases using CLN5 Batten disease iPSC-derived neurons
Dr Manju Kurian Great Ormond Street Hospital £90,885 Developing a patient-centric model to understand childhood-onset metal-related neurodegeneration: moving towards novel treatments
Dr Matthew Fenton Great Ormond Street Hospital £96,851 Donor derived Cell Free DNA – A liquid biopsy following  solid organ transplantation
Professor Mark Peters Great Ormond Street Hospital £99,018 Safety and feasibility of a clinical trial of permissive hypoxia in paediatric critical illness
Professor Ruth Gilbert UCL Great Ormond Street Institute of Child Health £99,463 Head or Heart study 
Dr Owen Arthurs Great Ormond Street Hospital £99,287 Development of micro-CT technology for fetal and perinatal minimally invasive autopsy

2015–2016 funding call

We received a total of 26 outline applications in response to the charity's call for applications.

Following a triage meeting held on 28 January 2015, 15 full applications were invited to be submitted for full external peer review.

The charity's Research Assessment Panel met on 3 June 2015 to review these applications.

The following six projects totalling £466,158 were awarded grants.

Lead investigator Host institution Total Project title
Professor Paul Gissen UCL Institute of Child Health £74,718 Implementation of a gene therapy platform for inherited metabolic liver disease: urea cycle defects
Professor Khalid Hussain UCL Institute of Child Health £50,000 Using iduced pluripotent stem cell (iPSC) derived beta-cells to understand the molecular mechanisms of hyperinsulinaemic hypoglycaemia
Professor Francesco Muntoni UCL Institute of Child Health £99,537 Exploring the microvascular abnormalities in spinal muscular atrophy
Dr Padmanabhan Ramnarayan Great Ormond Street Hospital £72,068 Enhancing patient comfort and improving patient flow in intensive care: a randomised feasibility study comparing first-line non-invasive respiratory support modalities in critically ill children
Professor Lyn Chitty Great Ormond Street Hospital £72,260 Development of a measure of parental informed consent for whole genome sequencing at Great Ormond Street Hospital
Professor Shamima Rahman UCL Institute of Child Health £97,575 Translational read-through therapy for metabolic diseases: a proof of principle study

2014–2015 funding call

We received a total of 33 outline applications in response to the charity's call for applications. Two of these withdrew.

Following a triage meeting held on 4 February 2014, 12 full applications were invited to be submitted for full external peer review.

The charity's Research Assessment Panel met on 9 June 2014 to review these applications.

The following seven projects totalling £500,000 were awarded grants.

Lead investigator Host institution Total Project title
Dr Dora Wood Great Ormond Street Hospital £29,723 A comparison of outcomes for teenagers cared for in adult intensive care units (AICU) and paediatric intensive care units (PICU): implications for PICU capacity planning
Professor Chris O'Callaghan UCL Institute of Child Health £74,409 Preventing ventilator associated pneumonia on intensive care: Bacteriophage therapy 
Dr Padmanabhan Ramnarayan Great Ormond Street Hospital £43,236 Quality of life and functional outcomes 12 months after emergency admission to paediatric intensive care
Dr Sandra Walsh Great Ormond Street Hospital £75,966 Optimising efficacy and minimising toxicity of intravenous salbutamol in children with acute severe asthma
Dr Isabel Heyman UCL Institute of Child Health £68,961 Integrating mental and physical healthcare: A pilot project
Dr Juan Pablo Kaski Great Ormond Street Hospital £72,501 The BIOPIC (BIOmarkers in Paediatric Inherited Cardiovascular disease) Study: Measuring biomarkers to understand disease pathophysiology and assessing their use for diagnostic and prognostic purposes in paediatric inherited cardiovascular disease
Dr Paolo de Coppi UCL Institute of Child Health £135,204 Development of a functional tissue-engineered intestine

2013–2014 funding call

We received a total of 51 outline applications in response to the charity's call for applications.

Following a triage meeting held on 15 October 2012, 15 full applications were invited to be submitted for full external peer review.

The charity's Research Assessment Panel met on 4 February 2013 to review these applications.

The following five projects totalling £324,728 were awarded grants.

Lead investigator Host institution Total Project title
Dr Manju Kurian UCL Institute of Child Health £87,000 A gene therapy approach to childhood parkinsonism
Professor Mehul Dattani UCL Institute of Child Health £49,734 Quantification of oxytocin and arginine-vasopressin concentration in patients with complex hypothalamopituitary disorders including septo-optic dysplasia
Professor Lucy Wedderburn UCL Institute of Child Health £77,194 Using Muscle Biopsy Score Tool to predict disease outcome and severity in Juvenile Dermatomyositis
Dr Karin Straathof UCL Institute of Child Health £95,800 Towards T-cell immunotherapy for Diffuse Intrinsic Pontine Glioma: delivery of engineered T-cells to the tumour
Dr Lesley Rees Great Ormond Street Hospital £15,000 Calcium balance in children on dialysis: a pilot study to be followed by a trial of calcium barbonate versus calcium acetate