Research calls

Great Ormond Street Hospital Children's Charity is committed to supporting high quality research with the potential to improve the health and wellbeing of children at Great Ormond Street Hospital (GOSH), through better diagnosis, treatment, improved care and cures. Our niche is the rapid translation of research for patient benefit.

Clinical Research Starter Grants 2016-2017



Scope of call

The charity is inviting clinically focused pilot or feasibility studies that will help investigators gather proof-of-concept data needed to move the research into the next stage. This is intended to be pump-prime funding and it is expected that applicants will leverage the charity grant to obtain funding from the NIHR or another external funding body.

We particularly encourage proposals that:

  • Conduct research to improve health services provided by GOSH, aim to fill a clear evidence gap or are likely to lead to changes in practice1.
  • Evaluate the effectiveness of interventions and/or scrutinise innovations and developments.
  • Are highly translational and likely to benefit patients directly and address problems that will have an impact at the point-of-care.
  • Make the most of the unique patient population at GOSH.
  • Demonstrate real partnership between clinical and academic researchers. Rapid progress will often need a multidisciplinary approach, or sharing of resources and knowledge.

Applicants are reminded of the importance of clearly defining their study as a feasibility or pilot study2 along with a list of clear progression criteria to the main study.

1 Under this funding stream projects that aim to establish audits, databases and registries or are mainly service development will not be supported.

2 Pilot or feasibility studies as defined by the National Institute for Health Research

Funding available

Up to £500,000 is available to spend under this call and it is anticipated that we will fund a range of proposals from different investigators. Projects of up to 18 months duration will be considered, to a maximum cost of £100,000. Lead Applicants must be research active Great Ormond Street Hospital health professionals based at Great Ormond Street Hospital. Funding will be provided for the direct costs of research (such as research staff and consumables) and will not cover consultant PA’s or team-leader salary time.

How to apply

All applicants will need to complete the

If you require further information please email us.

Previous Clinical Research Starter Grant Funding Calls

2015-2016 Funding Call

We recieved a total of 26 outline applications in response to the charity's call for applications.

Following a triage meeting held on 28 January 2015, 15 full applications were invited to be submitted for full external peer review.

The charity's Research Assessment Panel (RAP) met on 3 June 2015 to review these applications.

The following six projects totalling £466,158 were awarded grants.

Lead investigator Host institution Total Project title
Paul Gissen UCL Institute of Child Health £74,718 Implementation of a gene therapy platform for inherited metabolic liver disease: urea cycle defects
Khalid Hussain UCL Institute of Child Health £50,000 Using iduced pluripotent stem cell (iPSC) derived beta-cells to understand the molecular mechanisms of hyperinsulinaemic hypoglycaemia
Francesco Muntoni UCL Institute of Child Health £99,537 Exploring the microvascular abnormalities in spinal muscular atrophy
Padmanabhan Ramnarayan Great Ormond Street Hospital £72,068 Enhancing patient comfort and improving patient flow in intensive care: a randomised feasibility study comparing first-line non-invasive respiratory support modalities in critically ill children
Lyn Chitty Great Ormond Street Hospital £72,260 Development of a measure of parental informed consent for whole genome sequencing at Great Ormond Street Hospital
Shamima Rahman UCL Institute of Child Health £97,575 Translational read-through therapy for metabolic diseases: a proof of principle study


Previous National Funding Calls

AMR logo
Joint call for project grants from across the UK from Action Medical Research and Great Ormond Street Hospital Children’s Charity 2015-2016

We received a total of 115 outline applications in response to the charities' joint national call.

Following triage, 59 outline applications were invited to submit full applications with 54 being received and put forward for full external peer review.

AMR's Scientific Advisory Board (SAB) met on 8 June 2015 to review these applications. Two of Great Ormond Street Hospital Children's Charity's Research Assessment Panel (RAP) members provided written comments in advance of the meeting (Professor Stephen Holgate and Professor David Goldblatt) and one member was in attendence of the meeting (Dr Colin Michie).

The following 13 projects were awarded joint funding, totalling £2,050,839 or £1,025,422 per charity.

Lead investigator Host institution Total Project title
John Anderson UCL Institute of Child Health £197,027 Optimising cellular immunotherapy for neuroblastoma.
Georgina Jackson University of Nottingham £97,651 Learning and breaking habits in tourette syndrome.
Judy Breuer University College London £62,911 Use of target enrichment deep sequencing and data modelling to improve the management of cytomegalovirus in immunocompromised patients at GOSH.
Lyn Chitty Great Ormond Street Hospital £198,634 Developing safe, early non-invasive prenatal diagnosis for autosomal recessive conditions: cystic fibrosis and spinal muscular atrophy
Bobby Gaspar UCL Institute of Child Health £165,929 Adoptive transfer of autologous gene corrected T cells to treat X-linked lymphoprofilerative disease (XLP).
Deborah Tweddle Newcastle University £196,219 Clinical and biological factors associated with relapse and length of survival following relapse in UK neuroblastomas.
Mark Johnson Birkbeck University of London £199,987 Identifying early infant treatment targets for neurocognitive development in neurofibromatosis type 1.
Antonia Valentin Kings College London £164,253 Brain electrical stimulation for the treatment of severe epilepsies in children.
Nick Greene UCL Institute of Child Health £177,915 Disease of the glycine cleavage system: understanding the causes and development of novel therapies.
Michael Clarke University College London £88,438 Development of an eye-pointing classifcation scale for young non-speaking children with severe cerebral palsy.
Pablo Lamata Kings College London £102,593 Improving surgical decisions in hypoplastic left heart syndrome (HLHS) through computational cardiac models.
David Sharp Imperial College London £199,814 Network dysfunction following paediatric traumatic brain injury.
Owen Williams UCL Institute of Child Health £199,465 Harnessing TEL-AML1-induced signalling pathways for targeted therapy of t(12:21) leukaemia.

Research homepage
Translational Paediatric Rare Disease Research 2014-2015

We received a total of 43 outline applications in response to the charity’s national call for outline proposals in November 2013.

Following a triage meeting held on 19 December 2013, 11 full applications were invited to be submitted in February 2014 for full external peer review.

A National Assessment Panel met on 12 May 2014 to review these applications. Present at the meeting were Professor Timothy Barrett, Dr Colin Michie, Dr William Van't Hoff, Professor Phillip Beales, Professor David Jones, Professor Jill Clayton-Smith, Professor Andy Copp and Dr Sahar Mansour.

The following seven projects totalling £1,000,000 were awarded grants:

Table showing the seven projects awarded grants for the Translational Paediatric Rare Disease Research funding call in 2014-2015.

Lead investigator Host institution Total Project title
John Anderson UCL Institute of Child Health £33,000 Exploring gene therapy approaches for neuroblastoma using a patient's own gamma delta T cells: Application for running costs.
Philippa Mills UCL Institute of Child Health £110,197 Rapid identification of children whose epilepsy can be treated with vitamin B6.
Philip Stanier UCL Institute of Child Health £134,026 Clinical and molecular characterisation of a new intellectual disability-cerebellar ataxia syndrome.
Brian Bigger University of Manchester £358,626 Development of myeloid driven autologous haematopoietic stem cell gene therapy for Sanfilippo disease.
Phillip Beales UCL Institute of Child Health £30,506 Evaluating alternative genetic therapies for Bardet-Biedl Syndrome.
Hannah Mitchison UCL Institute of Child Health £133,489 Next generation sequencing to stratify and personalise the genetic basis of motile cilia disease.
Fenella Kirkham UCL Institute of Child Health £200,156 Potential Reversibility of structural brain abnormalities by preventing hypoxia in sickle cell anaemia.