National calls

Joint call for project grants from across the UK from Action Medical Research (AMR) and Great Ormond Street Hospital Children’s Charity 2015–2016

We received a total of 115 outline applications in response to the charities' joint national call.

Following triage, 59 outline applications were invited to submit full applications with 54 being received and put forward for full external peer review.

AMR's Scientific Advisory Board met on 8 June 2015 to review these applications. Two of Great Ormond Street Hospital Children's Charity's Research Assessment Panel members provided written comments in advance of the meeting (Professor Stephen Holgate and Professor David Goldblatt) and one member was in attendance of the meeting (Dr Colin Michie).

The following 13 projects were awarded joint funding, totalling £2,050,839.

Lead investigator Host institution Total Project title
Professor John Anderson UCL Institute of Child Health £197,027 Optimising cellular immunotherapy for neuroblastoma
Professor Georgina Jackson University of Nottingham £97,651 Learning and breaking habits in tourette syndrome
Professor Judy Breuer University College London £62,911 Use of target enrichment deep sequencing and data modelling to improve the management of cytomegalovirus in immunocompromised patients at GOSH
Professor Lyn Chitty Great Ormond Street Hospital £198,634 Developing safe, early non-invasive prenatal diagnosis for autosomal recessive conditions: cystic fibrosis and spinal muscular atrophy
Professor Bobby Gaspar UCL Institute of Child Health £165,929 Adoptive transfer of autologous gene corrected T cells to treat X-linked lymphoprofilerative disease (XLP)
Professor Deborah Tweddle Newcastle University £196,219 Clinical and biological factors associated with relapse and length of survival following relapse in UK neuroblastomas
Professor Mark Johnson Birkbeck University of London £199,987 Identifying early infant treatment targets for neurocognitive development in neurofibromatosis type 1
Dr Antonio Valentin Kings College London £164,253 Brain electrical stimulation for the treatment of severe epilepsies in children
Professor Nick Greene UCL Institute of Child Health £177,915 Disease of the glycine cleavage system: understanding the causes and development of novel therapies
Dr Michael Clarke University College London £88,438 Development of an eye-pointing classifcation scale for young non-speaking children with severe cerebral palsy
Dr Pablo Lamata Kings College London £102,593 Improving surgical decisions in hypoplastic left heart syndrome (HLHS) through computational cardiac models
Professor David Sharp Imperial College London £199,814 Network dysfunction following paediatric traumatic brain injury
Dr Owen Williams UCL Institute of Child Health £199,465 Harnessing TEL-AML1-induced signalling pathways for targeted therapy of t(12:21) leukaemia

Translational paediatric rare disease research 2014–2015

We received a total of 43 outline applications in response to the charity’s national call for outline proposals in November 2013.

Following a triage meeting held on 19 December 2013, 11 full applications were invited to be submitted in February 2014 for full external peer review.

A National Assessment Panel met on 12 May 2014 to review these applications. Present at the meeting were Professor Timothy Barrett, Dr Colin Michie, Dr William Van't Hoff, Professor Phillip Beales, Professor David Jones, Professor Jill Clayton-Smith, Professor Andy Copp and Dr Sahar Mansour.

The following seven projects totalling £1,000,000 were awarded grants.

Lead investigator Host institution Total Project title
Professor John Anderson UCL Institute of Child Health £33,000 Exploring gene therapy approaches for neuroblastoma using a patient's own gamma delta T cells: Application for running costs
Dr Philippa Mills UCL Institute of Child Health £110,197 Rapid identification of children whose epilepsy can be treated with vitamin B6
Professor Philip Stanier UCL Institute of Child Health £134,026 Clinical and molecular characterisation of a new intellectual disability-cerebellar ataxia syndrome
Dr Brian Bigger University of Manchester £358,626 Development of myeloid driven autologous haematopoietic stem cell gene therapy for Sanfilippo disease
Professor Philip Beales UCL Institute of Child Health £30,506 Evaluating alternative genetic therapies for Bardet-Biedl Syndrome
Dr Hannah Mitchison UCL Institute of Child Health £133,489 Next generation sequencing to stratify and personalise the genetic basis of motile cilia disease
Professor Fenella Kirkham UCL Institute of Child Health £200,156 Potential Reversibility of structural brain abnormalities by preventing hypoxia in sickle cell anaemia

Biomarker research 2013–2014

We received a total of 43 outline applications in response to the charity’s national call for outline proposals in November 2013.

Following a triage meeting held on 4 December 2012, 16 full applications were invited to be submitted for full external peer review.

A National Assessment Panel met on 28 June 2013 to review these applications. Present at the meeting were Professor David Armstrong, Professor Bobby Gaspar, Dr Colin Michie, Professor Tim Barrett, Dr Peter Grabowski and Dr William V’ant.

The following six projects totalling £947,574 were awarded grants.

Lead investigator Host institution Total Project title
Dr Paul Humphries University College London £100,500 Whole body PET-MRI in paediatric and adolescent lymphoma
Professor Michael Levin Imperial College London £260,246 Development of a rapid diagnostic test to discriminate bacterial and viral infection in febrile children based on an RNA expression signature
Dr David Michod UCL Institute of Child Health £40,500 Phosphorylation of the H3.3 chaperone DAXX as a new biomarker and a new target for treatment of high grade gliomas in children
Dr David Long UCL Institute of Child Health £195,526 Angio-poietin-2 as a biomarker and mediator of cardiovascular disease in children
Dr Vivek Muthurangu UCL Institute of Cardiovascular Science £184,975 Magnetic resonance augmented exercise testing: a novel biomarker in paediatric pulmonary hypertension
Professor Kathy Pritchard-Jones UCL Institute of Child Health £165,827 Prognostic value of 1q gain in Wilms’ tumour