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Please find full details of the funding call below.

GOSH Charity LifeArc Funding Call 2021 (.pdf) (223.7 KB)

Remit

GOSH Charity and LifeArc are inviting translational, milestone-driven applications which aim to improve the prevention, diagnosis, prognosis, or treatment of rare disease or that focus on developing research tools that increase the efficiency of developing interventions in rare disease. The scheme is designed to support applications on the translational pathway with the expectation that researchers will continue to develop their therapy/ diagnostic after GOSH charity/LifeArc funding, either by securing further funding from external translational schemes (from funders such as the Medical Research Council, National Institute for Health Research, Innovate UK and others), or partnering with/ licensing to industry.

Applications should:

  • Address a rare disease medical need
  • Have a strong scientific rationale
  • Be a target-driven milestoned project with a credible delivery plan
  • Have a clear route to patient
  • Make the most of the unique patient populations at GOSH

The following activities are eligible for support:

  • Developing candidate therapeutic entities (e.g. drug discovery)
  • Pre-clinical testing of novel therapeutic entities in vitro or in vivo
  • Pre-clinical validation for repurposed therapeutics
  • Early-phase clinical trials of novel therapeutic entities (phases 1/2)
  • Clinical trials of existing therapeutics repurposed for a new indication
  • Developing and testing novel devices
  • Developing and testing diagnostics (including biomarker validation)

All modalities of intervention are eligible for support from the scheme, including small molecules, peptides, antibodies, vaccines, regenerative medicine, cell and gene therapy, devices, surgical techniques and psychological approaches. An indication of where this scheme fits within the wider translational funding pathway can be seen in the funding call document.

The following activities are not eligible for support:

  • Fundamental or investigative research that does not link to a development plan
  • Studies where the primary purpose is to investigate disease mechanism
  • Late-phase clinical trials

If you have any questions about this, please contact grants@gosh.org.

Applicant Eligibility

Projects must be led by research active professionals based at GOSH or the UCL Great Ormond Street Institute of Child Health. Collaborations with industry and other academic partners are encouraged where relevant to the project. Lead applicants may only submit one application per round.

Funding Available

There is a total of £1million available under this call. There is no formal upper limit on the funds that can be applied for, but it is anticipated that we will fund a small number of high-quality projects of up to three years duration. Applicants should note that continued funding will be subject to the achievement of the corresponding milestones.

Application Process

Before applying, applicants are recommended to contact the grants team by emailing grants@gosh.org to discuss the eligibility of their proposed project.

1:1 pre-application sessions with a representative from LifeArc and GOSH charity are available to provide support to applicants about their proposed applications to the scheme. Please contact the grants team for more information.

This is a two-stage application process:

  1. Applicants are required to submit an outline application form through the charity’s online application portal which will be reviewed by GOSH Charity’s Research Assessment Panel.
  2. Successful applicants will then be invited to submit a full application which will undergo external peer review and further review by the Research Assessment Panel.

Webinar and Feedback Sessions

GOSH Children’s Charity and LifeArc will be running a webinar to provide further information about the call and assist applicants with their applications. The webinar will include representation from LifeArc, the Chair of the GOSH Charity Research Assessment Panel, the UCL TRO and the Joint GOSH and ICH R&D Office.

Webinar– 25 February 2021 13.30 -15.00 This workshop is aimed at those who are interested in submitting an outline application. The aim of this workshop is to:

  • Provide information about the scheme and the types of applications we are looking for.
  • Provide an opportunity for applicants to ask questions about the scheme and the application process.

For further details about the webinar and to register your interest visit this link.

Deadline

The deadline for submission of outline applications is Noon 16 April 2021.